Blueprints for Healing: Central Nervous System Regeneration in Zebrafish and Neonatal Mice. Cellini B, Vayankara Edachola S, Faw TD, Cigliola V. BMC Biology. 2025 In Press.
In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration. Becker CJ, Cigliola V, Gillotay P, Rich A, De Simone A, Han Y, Di Talia S, Poss KD. Development. 2023 Nov. doi: 10.1242/dev.202076.
Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Cigliola V, Shoffner A, Lee N, Ou J, Gonzalez TJ, Hoque J, Becker CJ, Han Y, Shen G, Faw TD, Abd-El-Barr MM, Varghese S, Asokan A, Poss KD. Nature Communications. 2023 Aug. doi: 10.1038/s41467-023-40486-5.
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. Cell Stem Cell. 2023 Jan. doi: 10.1016/j.stem.2022.11.012.
Transgenic mice for in vivo epigenome editing with CRISPR-based systems. Gemberling MP, Siklenka K, Rodriguez E, Tonn-Eisinger KR, Barrera A, Liu F, Kantor A, Li L, Cigliola V, Hazlett MF, Williams CA, Bartelt LC, Madigan VJ, Bodle JC, Daniels H, Rouse DC, Hilton IB, Asokan A, Ciofani M, Poss KD, Reddy TE, West AE, Gersbach CA. Nat Methods. 2021 Aug. doi: 10.1038/s41592-021-01207-2.
Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss. Oropeza D, Cigliola V, Romero A, Chera S, Rodríguez-Seguí SA, Herrera PL. BMC Genomics. 2021 Aug. doi: 10.1186/s12864-021-07812-x.
Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production. Perez-Frances M, van Gurp L, Abate MV, Cigliola V, Furuyama K, Bru-Tari E, Oropeza D, Carreaux T, Fujitani Y, Thorel F, Herrera PL. Nat Commun. 2021 Jul. doi: 10.1038/s41467-021-24788-0.
Tp53 suppression promotes cardiomyocyte proliferation during zebrafish heart regeneration. Shoffner A, Cigliola V, Lee N, Ou J, Poss KD. Cell Rep. 2020 Sep. doi: 10.1016/j.celrep.2020.108089.
Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. Thompson JD, Ou J, Lee N, Shin K, Cigliola V, Song L, Crawford GE, Kang J, Poss KD. Development. 2020 Jul. doi: 10.1242/dev.191262.
Building bridges, not walls: spinal cord regeneration in zebrafish. Cigliola V, Becker CJ, Poss KD. Dis Model Mech. 2020 May. doi: 10.1242/dmm.044131.
Tissue repair brakes: A common paradigm in the biology of regeneration. Cigliola V, Ghila L, Chera S, Herrera PL. Stem Cells. 2020 Mar. doi: 10.1002/stem.3118.
Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. Han Y, Chen A, Umansky KB, Oonk KA, Choi WY, Dickson AL, Ou J, Cigliola V, Yifa O, Cao J, Tornini VA, Cox BD, Tzahor E, Poss KD. Dev Cell. 2019 Mar. doi: 10.1016/j.devcel.2019.01.001.
Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL. Nat Cell Biol. 2018 Nov. doi: 10.1038/s41556-018-0216-y.
Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo. Berchtold LA, Miani M, Diep TA, Madsen AN, Cigliola V, Colli M, Krivokapic JM, Pociot F, Eizirik DL, Meda P, Holst B, Billestrup N, Størling J. Mol Cell Endocrinol. 2017 Jun. doi: 10.1016/j.mce.2017.04.001.
Stress-induced adaptive islet cell identity changes. Cigliola V, Thorel F, Chera S, Herrera PL. Diabetes Obes Metab. 2016 Sep. doi: 10.1111/dom.12726.
A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells. Cigliola V, Populaire C, Pierri CL, Deutsch S, Haefliger JA, Fadista J, Lyssenko V, Groop L, Rueedi R, Thorel F, Herrera PL, Meda P. PLoS One. 2016 Mar. doi: 10.1371/journal.pone.0150880.
Role of Connexins and Pannexins in the Pancreas. Cigliola V, Allagnat F, Berchtold LA, Lamprianou S, Haefliger JA, Meda P. Pancreas. 2015 Nov. doi: 10.1097/MPA.0000000000000378.
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL. Nature. 2014 Oct. doi: 10.1038/nature13633.
Connexins and β-cell functions. Cigliola V, Chellakudam V, Arabieter W, Meda P. Diabetes Res Clin Pract. 2013 Mar. doi: 10.1016/j.diabres.2012.10.016.
Cx36 is a target of Beta2/NeuroD1, which associates with prenatal differentiation of insulin-producing β cells. Nlend RN, Aït-Lounis A, Allagnat F, Cigliola V, Charollais A, Reith W, Haefliger JA, Meda P. J Membr Biol. 2012 Jun. doi: 10.1007/s00232-012-9447-1.
Connexin-dependent signaling in neuro-hormonal systems. Potolicchio I, Cigliola V, Velazquez-Garcia S, Klee P, Valjevac A, Kapic D, Cosovic E, Lepara O, Hadzovic-Dzuvo A, Mornjacovic Z, Meda P. Biochim Biophys Acta. 2012 Aug. doi: 10.1016/j.bbamem.2011.09.022.
In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration. Becker CJ, Cigliola V, Gillotay P, Rich A, De Simone A, Han Y, Di Talia S, Poss KD. Development. 2023 Nov. doi: 10.1242/dev.202076.
Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Cigliola V, Shoffner A, Lee N, Ou J, Gonzalez TJ, Hoque J, Becker CJ, Han Y, Shen G, Faw TD, Abd-El-Barr MM, Varghese S, Asokan A, Poss KD. Nature Communications. 2023 Aug. doi: 10.1038/s41467-023-40486-5.
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. Cell Stem Cell. 2023 Jan. doi: 10.1016/j.stem.2022.11.012.
Transgenic mice for in vivo epigenome editing with CRISPR-based systems. Gemberling MP, Siklenka K, Rodriguez E, Tonn-Eisinger KR, Barrera A, Liu F, Kantor A, Li L, Cigliola V, Hazlett MF, Williams CA, Bartelt LC, Madigan VJ, Bodle JC, Daniels H, Rouse DC, Hilton IB, Asokan A, Ciofani M, Poss KD, Reddy TE, West AE, Gersbach CA. Nat Methods. 2021 Aug. doi: 10.1038/s41592-021-01207-2.
Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss. Oropeza D, Cigliola V, Romero A, Chera S, Rodríguez-Seguí SA, Herrera PL. BMC Genomics. 2021 Aug. doi: 10.1186/s12864-021-07812-x.
Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production. Perez-Frances M, van Gurp L, Abate MV, Cigliola V, Furuyama K, Bru-Tari E, Oropeza D, Carreaux T, Fujitani Y, Thorel F, Herrera PL. Nat Commun. 2021 Jul. doi: 10.1038/s41467-021-24788-0.
Tp53 suppression promotes cardiomyocyte proliferation during zebrafish heart regeneration. Shoffner A, Cigliola V, Lee N, Ou J, Poss KD. Cell Rep. 2020 Sep. doi: 10.1016/j.celrep.2020.108089.
Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. Thompson JD, Ou J, Lee N, Shin K, Cigliola V, Song L, Crawford GE, Kang J, Poss KD. Development. 2020 Jul. doi: 10.1242/dev.191262.
Building bridges, not walls: spinal cord regeneration in zebrafish. Cigliola V, Becker CJ, Poss KD. Dis Model Mech. 2020 May. doi: 10.1242/dmm.044131.
Tissue repair brakes: A common paradigm in the biology of regeneration. Cigliola V, Ghila L, Chera S, Herrera PL. Stem Cells. 2020 Mar. doi: 10.1002/stem.3118.
Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. Han Y, Chen A, Umansky KB, Oonk KA, Choi WY, Dickson AL, Ou J, Cigliola V, Yifa O, Cao J, Tornini VA, Cox BD, Tzahor E, Poss KD. Dev Cell. 2019 Mar. doi: 10.1016/j.devcel.2019.01.001.
Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL. Nat Cell Biol. 2018 Nov. doi: 10.1038/s41556-018-0216-y.
Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo. Berchtold LA, Miani M, Diep TA, Madsen AN, Cigliola V, Colli M, Krivokapic JM, Pociot F, Eizirik DL, Meda P, Holst B, Billestrup N, Størling J. Mol Cell Endocrinol. 2017 Jun. doi: 10.1016/j.mce.2017.04.001.
Stress-induced adaptive islet cell identity changes. Cigliola V, Thorel F, Chera S, Herrera PL. Diabetes Obes Metab. 2016 Sep. doi: 10.1111/dom.12726.
A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells. Cigliola V, Populaire C, Pierri CL, Deutsch S, Haefliger JA, Fadista J, Lyssenko V, Groop L, Rueedi R, Thorel F, Herrera PL, Meda P. PLoS One. 2016 Mar. doi: 10.1371/journal.pone.0150880.
Role of Connexins and Pannexins in the Pancreas. Cigliola V, Allagnat F, Berchtold LA, Lamprianou S, Haefliger JA, Meda P. Pancreas. 2015 Nov. doi: 10.1097/MPA.0000000000000378.
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL. Nature. 2014 Oct. doi: 10.1038/nature13633.
Connexins and β-cell functions. Cigliola V, Chellakudam V, Arabieter W, Meda P. Diabetes Res Clin Pract. 2013 Mar. doi: 10.1016/j.diabres.2012.10.016.
Cx36 is a target of Beta2/NeuroD1, which associates with prenatal differentiation of insulin-producing β cells. Nlend RN, Aït-Lounis A, Allagnat F, Cigliola V, Charollais A, Reith W, Haefliger JA, Meda P. J Membr Biol. 2012 Jun. doi: 10.1007/s00232-012-9447-1.
Connexin-dependent signaling in neuro-hormonal systems. Potolicchio I, Cigliola V, Velazquez-Garcia S, Klee P, Valjevac A, Kapic D, Cosovic E, Lepara O, Hadzovic-Dzuvo A, Mornjacovic Z, Meda P. Biochim Biophys Acta. 2012 Aug. doi: 10.1016/j.bbamem.2011.09.022.
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